Preheat the air fryer to 375°F (190°C). Give the basket a light spray with oil to help prevent sticking.

Make the patties: In a bowl, combine ground bison with 1 teaspoon kosher salt, 1/2 teaspoon pepper, 1/2 teaspoon garlic powder, 1/2 teaspoon onion powder, and 1 teaspoon Worcestershire. Mix gently with your hands until just combined.

Form and flatten: Divide into 3–4 equal portions. Shape into patties about 1/2 inch thick and slightly wider than your buns. Press a small dimple in the center of each to prevent doming.

Air fry the burgers: Place patties in a single layer in the basket with space between them. Cook for 6–8 minutes, then flip.

Finish cooking: Air fry another 3–5 minutes, depending on thickness and your preferred doneness. Aim for 135–140°F for medium-rare or 145°F for medium. Use an instant-read thermometer for accuracy.

Add cheese (optional): Lay a slice on each patty and cook 30–60 seconds more, just until melted.

Toast the buns: Remove burgers. Lightly butter buns or spread with mayo and air fry cut-side up for 1–2 minutes until golden.

Assemble: Add burgers to buns, pile on toppings, and finish with your favorite condiments. Serve immediately.